Kourtney Kardashian Barker’s Lemme Supplement Brand Debuts a ‘Natural Alternative to Ozempic’—Is It Legit?

Based on a press launch from the model, the brand new complement is meant to “increase the physique’s GLP-1 ranges, scale back starvation, promote insulin sensitivity, and assist wholesome weight administration.” The capsules are supposed to be taken as soon as every day for 3 to 6 months for greatest outcomes, per the model’s web site.

Dietary supplements like Wegovy and Ozempic are GLP-1 agonists, that means they mimic GLP-1 in your physique, a naturally occurring hormone that helps regulate blood sugar, urge for food, and digestion. These medicine can be found solely by prescription to deal with circumstances comparable to kind 2 diabetes and weight problems.

Whereas Lemme’s new complement has “GLP-1” within the title, it doesn’t truly comprise any of the artificial hormone. So regardless of its intelligent advertising, it is not an over-the-counter model of Ozempic (and since it is a complement and never a drug, it is not as well-regulated by the FDA). As a substitute, it is made with a mix of herbs, together with lemon fruit extract, saffron extract, and purple orange fruit extract.

Right here, we’ll dig into the analysis across the new complement’s elements, what we find out about their security and efficacy, and whether or not it is price your cash.

Elements in Lemme GLP-1 Day by day

The principle energetic elements on this complement are lemon fruit extract (200 mg), saffron extract (176.5 mg), and purple orange fruit extract (400 mg). All are herbs which were utilized in conventional drugs practices. Here is what analysis says about their impact on weight reduction and GLP-1 ranges.

Lemon fruit extract

Lemon fruit extract is a citrus flavonoid that comes from lemon juice and peel. There’s very restricted analysis on the extract in people, however here is what we all know to this point: Final 12 months, a double-blind, randomized managed trial in Meals Science & Diet discovered that Eriomin (a brand-name lemon fruit extract) had a reasonably optimistic impact on intestine flora, GLP-1 ranges, and blood sugar. However this examine was very small (solely 30 individuals made it to the top of the 12-week interval) and all members had prediabetes—that means we will not say whether or not these optimistic outcomes prolong to individuals with out prediabetes. It additionally makes no point out of how Eriomin affected members’ urge for food or weight.

One other July 2019 examine in Phytotherapy Analysis discovered comparable outcomes, in that Eriomin barely improved blood sugar and GLP-1 ranges, however this examine was additionally small (involving solely about 100 individuals) and once more solely included individuals who had prediabetes.

Each research solely adopted members for 12 weeks, so we do not know a lot about its long-term results. This additionally means no secure or efficient dosage has been established.

Saffron extract

Saffron is an antioxidant-rich spice that is usually utilized in holistic drugs for its purported advantages on sleep, temper points, and irritation, per a February 2022 article in Vitamins. The few research which have checked out its impact on weight found little optimistic outcomes.

Whereas one older 2010 examine in Diet Analysis suggests saffron extract could barely scale back snacking when in comparison with a placebo, it didn’t trigger vital weight reduction. Extra present analysis additionally reveals the extract has little to no impact on weight, BMI, or waist or hip circumference (although taking it did barely lower waist-to-hip ratio in some individuals), in accordance with a July 2022 meta-analysis of 25 research in Phytotherapy Analysis⁵.

General, there’s not sufficient proof to point out that saffron may also help you drop some pounds or assist management blood sugar.

Crimson orange fruit extract

The third important ingredient in Lemme GLP-1 Day by day is purple orange fruit extract, aka Morosil—an extract from Silician Moro blood oranges. It is extensively marketed as a pure complement to assist facilitate weight reduction and scale back belly fats. However the research inspecting its results are principally sponsored by corporations promoting the extract as a complement, that means there is a potential for findings to be biased.

For instance, one February 2022 double-blind, randomized managed trial in Vitamins discovered members with chubby who took Morosil for six months noticed diminished BMI and improved physique composition. Extra particularly, members misplaced about 4.2 % of their physique weight, in comparison with 2.2 % with the placebo. That stated, this examine was additionally small: Fewer than 200 individuals accomplished the total six months. And it was funded by Bionap—an organization that sells Morosil—so there’s additionally a possible battle of curiosity at play.

One other January 2015 randomized managed trial in Pure Product Analysis had members with chubby (who have been in any other case wholesome) take Morosil for 12 weeks. After 4 weeks, members noticed a major discount in BMI in comparison with the group who took a placebo.

That stated, research on Morosil have been small and brief in length. Extra analysis is required to find out its long-term results, security, and superb dosage.

It is also necessary to notice that no analysis has seemed on the results of mixing these three elements, so we do not understand how they work together with each other.

Do these dietary supplements truly work? (And are they secure?)

Whereas there’s some analysis to assist that Eriomin and Morosil individually have an effect on GLP-1 pathways and result in slight weight reduction, they don’t seem to be practically as efficient as conventional GLP-1 medicine like Ozempic and Wegovy, which have been confirmed in medical trials to enhance GLP-1 ranges and promote vital weight reduction in individuals with chubby, per a January 2022 trial in JAMA. There’s nonetheless much more analysis to be executed on this complement’s elements—together with their efficacy, how they work when mixed, and what’s thought-about a secure dosage.

One good factor to notice: Lemme confirmed to Properly+Good that its GLP-1 Day by day dietary supplements have been third-party examined by NSF (a good shopper items testing group). NSF certification ensures that what’s listed on the product label is definitely within the complement itself, and within the quantities claimed, with out extra (probably dangerous) elements like heavy metals. This sort of testing, nonetheless, doesn’t evaluate the complement’s security or efficacy.

The underside line

In the end, if you’re contemplating taking a GLP-1 complement for weight reduction or to enhance your blood sugar, begin by speaking along with your physician. They will decide whether or not a GLP-1 complement is secure or best for you and presumably advocate different methods to handle your weight.

Meghan Garcia Webb, MD, beforehand advised Properly+Good that there are more practical methods for weight and blood sugar administration than taking a complement, and people embody: